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03/01/2019

New clue for cancer treatment could be hiding in microscopic molecular machine

Researchers have discovered a critical missing step in the production of proteasomes -- tiny structures in a cell that dispose of protein waste -- and found that carefully targeted manipulation of this step could prove an effective recourse for the treatment of cancer.


Source: https://www.sciencedaily.com/releases/2019/02/190226112337.htm

Antonia A. Nemec, Anna K. Peterson, Jennifer L. Warnock, Randi G. Reed, Robert J. Tomko. An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes. Cell Reports, 2019; 26 (2): 483 DOI: 10.1016/j.celrep.2018.12.042



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